Mathematically England needed a big win at the Stadio Olimpico and they did exactly that, running in seven tries in the Roman sunshine.
The 52-11 win was a hugely promising end to the campaign for Stuart Lancaster's men who now look ahead to the Summer tour of New Zealand and the Rugby World Cup in 2015 with great promise, with only a late French try in Round One the difference between them and a Grand Slam.
In a scratchy start, stand out man of the tournament Mike Brown took a neat offload from Luther Burrell to show the Italian cover a clean pair of heels. That score was followed by Owen Farrell, cutting a neat line off Danny Care to touch down.
Chasing a big score, errors were creeping into the English game but the hosts were unable to punish them with points. When England kept it simple, Billy Twelvetrees and Burrell were excelling in attack and Brown crossed for his second try showing great pace to burn away after a neat offload.
It was clear than England were growing in confidence against their beleaguered opponents and Jack Nowell touched down for his maiden international try, with Mike Brown showing the golden touch as the creator.
As England went after the cricket score needed to put pressure on the Irish, tries came from Mako Vunipola who benefitted from a sharp break and offload from Twelvetrees, Manu Tuilagi barged his way over on his return the international arena and captain Chris Robshaw slid over in added time with Leonardo Sarto darting over after intercepting.
From the perspective of the Gloucester trio, it was a bright afternoon in a team well on top. Ben Morgan worked hard against an Italian scrum admittedly on top and both Twelvetrees and May worked hard in midfield looking for room and chances. May constantly was on the shoulder of the try scorers and on another day would've crossed for his first international try.
In the middle of the three games, Wales turned on the style thumping 14-man Scotland 51-3 in Cardiff. Scotland had full back Stuart Hogg red carded for a late tackle and Wales capitalised on their numerical advantage running in seven tries.
Two players who will be plying their trade in Cherry and White next season, Richard Hibbard and Greig Laidlaw took one another on and it was the Welsh hooker and his team mates that recorded a big win against the lackluster Scots.
Ireland and the inspired Brian O'Driscoll on his final appearance for the Irish secured the RBS Six Nations Championship winning 22-20 against France. A late missed penalty from Jean-Marc Doussain and a disallowed try late on for the French gave the Irish the dramatic win.