As a result, Gloucester need to regroup quickly if they are to achieve their goal of clinching Heineken Cup rugby for next season.
To take on the challenge of winning for only the third time at Adams Park, Redpath duly makes five changes to his starting line up.
A new midfield partnership sees Henry Trinder, recovered from a broken jaw, line up alongside Tim Molenaar while Nick Runciman, a try scorer against the Chiefs, starts at scrum half.
Tom Savage partners Jim Hamilton in the second row in preference to Alex Brown who has been unwell this week while Peter Buxton takes over from the injured Matt Cox on the blindside flank.
Gloucester's remaining four games are against clubs that are currently below them in the table but Redpath dismissed any thoughts that this might make his team's run in any easier.
"Not at all. Two of them are in the bottom two and fighting for their lives and that always makes for a dangerous animal. You can come a cropper if you don't respect that.
"They (Wasps) have had a horrendous injury list and they've lost several players to retirement. But that means they have a lot of motivation and a point to prove.
"They've got a good group of players and are desperate to do well. Whether they're big name players or not is irrelevant. It goes back to people's character and desire on the day. When that's right, they're a handful for anyone.
"We have to get our mindset right. We have to carry ball, we have to work hard to get anything out of the game. It's going to be tough because it's a big game for both clubs."
Jonny May; Charlie Sharples, Henry Trinder, Tim Molenaar, James Simpson-Daniel; Freddie Burns, Nick Runciman; Dan Murphy, Scott Lawson, Rupert Harden; Tom Savage, Jim Hamilton; Peter Buxton, Akapusi Qera, Luke Narraway (capt)
Darren Dawidiuk, Yann Thomas, Shaun Knight, Alex Brown, Alasdair Strokosch, Dan Robson, Ryan Mills, Mike Tindall