There is just one change in the back line as Henry Trinder comes in for Mike Tindall in the midfield whereas the pack is where the majority of the changes take place.
Shaun Knight makes his first Premiership start at tight head and Hamilton forms a new second row partnership alongside Will James.
Meanwhile, fresh from an impressive performance in the Aviva Premiership A League on Monday evening, Andy Hazell returns at openside flanker while Tom Savage moves from the second row to the blindside flank.
Irish got off to a losing start last weekend as they finished on the wrong end of a 40-3 scoreline against Saracens at the London Double Header but Davies isn't reading too much into that performance.
"It's really about focusing on us. We've looked at London Irish and their game last weekend and they won't be taking too much out of it.
"They're definitely going to bounce back and be stronger because they're at home. They'll be disappointed with last weekend and we can't read too much into it.
"It's more really a case, and it always has been anyway, about us looking at ourselves and making sure we get our game right. If we do that, then we'll progress.
"It's been a difficult squad to select. We've got a lot of players who are performing at a similar level. It's very competitive. But that's great because they'll all drive each other on."
Jonny May; Charlie Sharples, Henry Trinder, Billy Twelvetrees, James Simpson-Daniel; Freddie Burns, Dan Robson; Nick Wood, Darren Dawidiuk, Shaun Knight; Will James, Jim Hamilton (capt); Tom Savage, Andy Hazell, Ben Morgan
Huia Edmonds, Dan Murphy, Rupert Harden, Sione Kalamafoni, Akapusi Qera, Dave Lewis, Mike Tindall, Martyn Thomas