Davies makes one injury enforced change with Matt Cox coming in for Sione Kalamafoni on the blindside flank, while Charlie Sharples is away with England and is replaced by Shane Monahan.
The remaining changes see Dan Murphy named as the loose head prop in place of Nick Wood, while Martyn Thomas gets the nod at full back ahead of Rob Cook. Cook and Wood are both named amongst the replacements.
Gloucester come into the game having defeated the Leicester Tigers last weekend, a hugely physical encounter. However, Davies told the media this week that the training schedule has been tweaked accordingly.
"It hasn't affected our preparations, it's just altered them a little. We had to give everything against Leicester so we've adjusted things a little and given the players a couple of days off.
"Hopefully, it'll pay dividends for us this weekend. The most important day of the week for us is matchday and, hopefully, we'll be in the right place physically and mentally."
Both squads have been affected by international call ups, but Davies is still expecting to come up against a powerful Quins outfit.
"They'll still be strong. You don't win this league without having a strong squad of players, and they did it with some style last season. They're the champions and will be favourites this weekend.
"We've just got to turn up with the same mentality we've had all season, to fight hard for the shirt and for each other."
Martyn Thomas; Shane Monahan, Mike Tindall (capt), Billy Twelvetrees, James Simpson-Daniel; Freddie Burns, Jimmy Cowan; Dan Murphy, Huia Edmonds, Rupert Harden; Tom Savage, Will James; Matt Cox, Akapusi Qera, Ben Morgan
Tommaso d'Apice, Nick Wood, Dario Chistolini, Peter Buxton, Gareth Evans, Dan Robson, Tim Molenaar, Rob Cook