Koree Britton comes in for Tommaso d'Apice at hooker while Harry Casson replaces the injured Elliott Stooke in the second row.
Kick off at Kingsholm is at 7:45pm. Tickets are still available, visit www.gloucesterrugby.co.uk, phone 0871 871 8781 (option 2) or call in at the ticket office at Kingsholm in person.
Martyn Thomas; Steph Reynolds, Drew Locke, Tim Molenaar, Ian Clark; Dan Robson, Dave Lewis; Yann Thomas, Koree Britton, Dario Chistolini; Will Graulich, Harry Casson; Ross Moriarty, Matt Cox, Peter Buxton (capt)
Tommaso d'Apice, Dan Murphy, Tom Heard, Ed King, Ben Sparks, Brad Field, George Boulton, tbc