Meanwhile, Sale are eight points clear of London Welsh at the foot of the table, so a win for the home team would go a long way towards securing Premiership safety.
Director of Rugby Nigel Davies keeps faith with the majority of the pack who started against Biarritz in the Amlin Challenge Cup last weekend, with the return of hooker Huia Edmonds to the starting line up the only change.
The back line sees more changes as Dan Robson, Shane Monahan, Billy Twelvetrees and Rob Cook are all restored to the starting line up. For Monahan, a try scorer against Biarritz, it's a first start since February 2nd.
Amongst the replacements, there is a welcome return to the matchday squad for England international number eight Ben Morgan, who injured an ankle while on Six Nations duty with England.
Speaking to the local media after the game, Forwards Coach Carl Hogg stressed that the squad has quickly put the European defeat behind them.
"Our focus is now obviously on the Aviva Premiership, and we have a huge opportunity. We've got three games left and we're sitting in fifth place, which is a good position.
"Sale is the first obstacle on Friday night, and it will be a big challenge for us. But, if we show the same level resilience and team spirit that we have over the course of the Premiership season, then we'll be in with a shout.
"We want to finish the season on a high. It'd be great to finish in the top four, but we have to get our performance right on the pitch.
"Sale are playing with a bit more confidence in recent weeks, they've had one or two results. But Friday night is about us, and the way we perform. We were disappointed after last Thursday night, and hopefully we'll see a reaction at Sale."
Rob Cook; Jonny May, Mike Tindall (capt), Billy Twelvetrees, Shane Monahan; Freddie Burns, Dan Robson; Nick Wood, Huia Edmonds, Dario Chistolini; Lua Lokotui, Will James; Tom Savage, Akapusi Qera, Sione Kalamafoni
Koree Britton, Dan Murphy, Yann Thomas, Ben Morgan, Andy Hazell, Dave Lewis, Henry Trinder, Charlie Sharples