Also coming into the starting line up is Fijian international flanker Akapusi Qera, as Director of Rugby Nigel Davies shuffles his back row.
Matt Kvesic moves from openside to blindside to accommodate Qera, while Sione Kalamafoni takes over from Ben Morgan at number eight, with Morgan named amongst the replacements.
With those exceptions, it's the same starting line up that took the field against Sale Sharks last weekend and, previewing the game with the media this week, Nigel Davies stressed that he's looking for a reaction at Allianz Park.
"We've made one or two changes but, in the main, it's up to the guys to redeem themselves really.
"There's some technical stuff that we have to get right in terms of the set piece. And, when we get more ball, we can actually dictate for longer periods of the game.
"It may not be a huge tactical game. It may well come down to whoever wants it the most. It's the sort of thing that Saracens pride themselves on, in terms of dominating the opposition and being more physical.
"It's a great challenge, it's exactly what we want. Probably the best fixture we could have had."
Rob Cook; Charlie Sharples, Henry Trinder, Billy Twelvetrees, James Simpson-Daniel; Freddie Burns, Tavis Knoyle; Nick Wood, Darren Dawidiuk, Rupert Harden; Tom Savage (capt), Lua Lokotui; Matt Kvesic, Akapusi Qera, Sione Kalamafoni
Koree Britton, Dan Murphy, Yann Thomas, Elliott Stooke, Ben Morgan, Dan Robson, Mike Tindall, Martyn Thomas