Experience will be provided by the likes of Knoyle and Martyn Thomas, another former Scarlet, while there is a welcome return following injury for Jonny Bentley.
The rest of the backline relies heavily on the Academy, with Andrew Bulumakau and Drew Cheshire set for senior bows.
The experience up front will come from Rupert Harden and Will James, although the rest of the pack, despite their youthful outlook, have all featured in first team squads this season, with the exception of Alex Woodburn who makes his full debut.
Martyn Thomas; Steph Reynolds, Andrew Bulumakau, Billy Burns, Drew Cheshire; Jonny Bentley, Tavis Knoyle; James Gibbons, Koree Britton, Rupert Harden; Will James (capt), Tom Hicks; Ross Moriarty, Alex Woodburn, Lewis Ludlow
Dan George, Dan Murphy, Tom Heard, Jonny Hill, Sione Kalamafoni, Reece Boughton, Lloyd Evans, Will Hayward