Leicester scrum-half Ben Youngs and Northampton lock Courtney Lawes will make their first starts for England in the match in Sydney.
Youngs and Lawes replace Danny Care and second row Simon Shaw respectively. Care and Shaw both drop to the bench.
The Gloucester duo of Dave Attwood and Paul Doran-Jones both miss out despite string displays in the 15-9 midweek victory over the Australian Barbarians.
15 Ben Foden (Northampton Saints); 14 Mark Cueto (Sale Sharks),13 Mike Tindall (Gloucester Rugby), 12 Shontayne Hape (Bath Rugby), 11 Chris Ashton (Northampton Saints); 10 Toby Flood (Leicester Tigers), 9 Ben Youngs (Leicester Tigers); 1 Tim Payne (London Wasps), 2 Steve Thompson (CA Brive), 3 Dan Cole (Leicester Tigers); 4 Courtney Lawes (Northampton Saints), 5 Tom Palmer (Stade Francais); 6 Tom Croft (Leicester Tigers), 7 Lewis Moody (Leicester Tigers) CAPTAIN, 8 Nick Easter (Harlequins)
16 George Chuter (Leicester Tigers), 17 David Wilson (Bath Rugby), 18 Simon Shaw (London Wasps), 19 James Haskell (Stade Francais), 20 Danny Care (Harlequins), 21 Jonny Wilkinson (RC Toulon), 22 Delon Armitage (London Irish)