Italian international Marco Bortolami returns to the second row as captain, England scrum-half Peter Richards is recalled in the number nine jersey, Iain Balshaw sits on the bench after recovering from an ankle injury and Alex Brown also makes the starting line-up.
In all, there are nine internationals from three different countries in Gloucester's starting line-up and three more on the bench.
"We can still control the outcome of the pool if we keep winning because Leinster have to come back to us, but we realise we are in last chance saloon now," head coach Dean Ryan told www.gloucesterrugby.co.uk
"But we will have more experience around and that is a massive positive for us, we will be inspired by the crowd and we want to get Kingsholm jumping to make it tough for Edinburgh.
"We acknowledge the challenge we face from a very good side but we are relishing this opportunity.
"This is a real opportunity for us and the squad, which is fantastic for them."
Gloucester's front five is made up entirely of internationals. Patrice Collazo starts at loosehead, Olivier Azam is at hooker and Carlos Nieto at tighthead form the front row, while Bortolami and Brown are the locks.
In the back row, Peter Buxton returns at number six, Jake Boer switches back to the openside and Luke Narraway is named at number eight.
The backline is also changed and Richards returns in a half-back combination that includes Willie Walker, who has started the last two games in that position against Bristol and Bath - Ryan Lamb has recovered from a rib injury and is named on the bench.
Anthony Allen and Mike Tindall form the centre combination; James Simpson-Daniel, Mark Foster and Olly Morgan complete the back three. Foster returned last weekend after recovering from a foot injury.
Gloucester's bench is no less experienced and includes internationals Balshaw, scrum-half Rory Lawson - who will face his former club - and prop Christian Califano.
The rest of the bench is made up by hooker Rob Elloway, lock Adam Eustace, number eight Adam Balding and Lamb.
GLOUCESTER (v Edinburgh, tomorrow, 3pm): Olly Morgan; James Simpson-Daniel, Mike Tindall, Anthony Allen, Mark Foster; Willie Walker, Peter Richards; Patrice Collazo, Olivier Azam, Carlos Nieto, Marco Bortolami (capt), Alex Brown, Peter Buxton, Jake Boer, Luke Narraway. Reps: Rob Elloway, Christian Califano, Adam Eustace, Adam Balding, Rory Lawson, Ryan Lamb, Iain Balshaw.
There are still tickets available for tomorrow's game and they are available from www.gloucesterrugby.co.uk or the ticket hotline number (option 2) on 0871 871 8781.
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