And the Kingsholm side hope to welcome back England Under-21 centre Anthony Allen in a strong side that contains plenty of Premiership experience.
He could be joined by fellow England Under-21 star Ryan Lamb, Rob Thirlby, Mark Cornwell and Quinton Davids.
Gloucester are top of their A League conference and beat Wasps 52-12 at Kingsholm earlier in the season. Gloucester have won five of their seven games and will face a Wasps side who are bottom of the table with only two wins.
Brad Davies will start at stand-off and Jack Forster will get another run at tighthead prop.
"This is obviously another highly important game and we have named a strong and experienced squad," said coach Carl Douglas. "We are going well in the Guinness A League and we are desperate to continue that form."
Gloucester's next home game in the A League is against Saracens on Monday, February 27 (7.30pm) and again the club is offering the incentive of a 'quid a kid' scheme for Under-16s.
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