Gloucester make a number of changes to the team that travels to NEC Harlequins for Saturday's Zurich Premiership game (Sat 5 Feb, Stoop, kick off 2pm).
Four Kingsholm forwards are involved in the England Vs Wales game in Cardiff on the same day, with Andy Hazell starting for England, James Forrester and Phil Vickery on the bench, and Mefin Davies lining up for Wales.
South African prop Christo Bezuidenhout comes in at loose-head for Gloucester, with Terry Sigley moving to the number three shirt. James Parkes replaces Mefin Davies at hooker, and Frenchman Noel Curnier is named on the bench.
Mark Cornwell starts in the second row alongside Alex Brown, and Peter Buxton starts at blind-side flanker, with captain Jake Boer moving to open-side in place of Hazell.
James Simpson-Daniel makes his return from injury and partners Seti Kiole on the wings. Marcel Garvey misses out due to mumps.
Andy Gomarsall and Henry Paul both returned from England training in the middle of the week and line-up in the Gloucester back line.
Quins have advised supporters without tickets not to travel, as they are not expecting tickets to be available on the day.
15. Jon Goodridge
14. Seti Kiole
13. Terry Fanolua
12. Henry Paul
11. James Simpson-Daniel
10. Duncan McRae
9. Andy Gomarsall
1. Christo Bezuidenhout
2. James Parkes
3. Terry Sigley
4. Mark Cornwell
5. Alex Brown
6. Peter Buxton
7. Jake Boer (c)
8. Adam Balding
Replacements: 16. Noel Curnier
17. Nick Wood
18. Adam Eustace
19. Luke Narraway
20. Alex Page
21. Nathan Mauger
22. Mark Foster
Speaking after the game, Charlie Sharples described it as 'the win that has eluded us.' The winger stressed that Gloucester had stayed positive after the first couple of weeks of the Aviva Premiership season and the 26-13 victory over Sale was a result of that focus.
Gloucester Rugby picked up their first win of the new Aviva Premiership season on Friday night, easing to a 26-13 win on the road at Sale Sharks. Director of Rugby David Humphreys was full of praise for his players on the night.
Defence Coach Jonny Bell was on media duties ahead of the Aviva Premiership fixture at Sale Sharks on Friday evening, and spoke about where Gloucester find themselves in terms of their form at the moment as well as how he's viewing their defensive displays so far.
Callum Braley, who skippered Gloucester United to a 22-19 Aviva Premiership A League win over Saracens Storm on Monday evening, paid tribute to his forwards and the younger players in what he described as not the prettiest of wins.
A desperately disappointing afternoon for Gloucester who, despite dominating possession and territory, were guilty of failing to make the most of it against a resolute Newcastle defence before the visitors pounced to snatch the win in the second half.
Mariano Galarza and Ross Moriarty are both back from injury as Gloucester entertain the Newcastle Falcons at Kingsholm in the Aviva Premiership (Saturday, kick off 3pm). Willi Heinz will skipper the side from scrum-half.