Gloucester's Olly Morgan starts at full-back for England U21s against Ireland at Dublin's Donnybrook ground on Friday 25th February, kick off 4pm.
Joining the squad for his first cap is Worcester back row Mark Hopley who starts at number eight in place of the injured Chris Goodman. An injury to Ross Broadfoot gives Falcons fly half Toby Flood his first start as Ryan Davis moves back to inside centre.
With Northampton Saints winger Paul Diggin also not considered due to injury, Topsy Ojo of London Irish joins the replacements.
Coach Nigel Redman said: "Ireland are always very strong and physical, particularly at home. We've watched their game against Scotland and they contested the breakdown very well and that's an area we needed to be sharper in.
"There are 10 changes to the starting side that played France for various reasons but all these guys train together as a squad during the week. Experience told us that we'd need this depth and that's the reason we extended the training squad to 26 players.
"As coaches it's a great chance for us to work with different players from all the clubs and get to know more about them and keep them all in our thoughts. At this level especially you don't always know who's going to be the best in a particular position and you have to consider everyone.
"Hopley was on the bench against Ireland for us last year and was a part of the trial games against France at the start of the season. We have some outstanding talent at back row with the likes of Goodman, Seymour, Rees, Haskell and Hopley and this is a fantastic opportunity for Mark.
"Opportunities come in many ways and injuries sometimes allow us to give some players the chance to come in and show us the work they've been doing and make us pick them next time.
"Topsy Ojo is another great example. He was in the U19 squad last year and he's in the Intermediate National Academy and he's available to us for the next two years."
15. Olly Morgan - Gloucester
14. Tom Biggs - Leeds Tykes
13. Matt Cornwell - Leicester Tigers
12. Ryan Davis - Bath
11. Tom Varndell - Leicester Tigers
10. Toby Flood - Newcastle Falcons
9. Ben Foden - Sale Sharks
1. Michael Cusack - Leeds Tykes
2. Neil Briggs - Rotherham
3. Aston Croall - Saracens
4. Richard Blaze - Worcester
5. Tom Ryder - Leicester Tigers
6. James Haskell - London Wasps
7. David Seymour - Saracens
8. Mark Hopley - Worcester
16. Stuart Mackie - Newcastle Falcons
17. Matt Hampson - Leicester Tigers
18. Sean Cox - Sale Sharks
19. Richard Thorpe - London Irish
20. Lee Dickson - Newcastle Falcons
21. Simon Whatling - Worcester
22. Topsy Ojo - London Irish
Speaking to GRTV this week, Director of Rugby David Humphreys reflected on last week's win in La Rochelle as well as an A League semi-final triumph, but insisted that focus has quickly switched to Sunday's crucial Aviva Premiership fixture at Bath.
Speaking to GRTV after the 40-29 Aviva A League win over Wasps Rugby, Academy Coach Rich Whiffin explained his pride in the squad to overcome a strong opponent and book their spot in next week's Aviva A League final.
Willi Heinz returned from injury to skipper Gloucester to a famous 16-14 win over Stade Rochelais on Saturday evening. Speaking after the game in France, Heinz admitted the win wasn't pretty but was full of courage and a great result for the club.
Billy Burns contributed all Gloucester's points in the 16-14 European Rugby Challenge Cup win in La Rochelle on Saturday evening, but dedicated the victory to the whole squad whilst also praising the travelling support.
Speaking after Gloucester's brave 16-14 win against Stade Rochelais which clinches a European Rugby Challenge Cup final spot, Director of Rugby David Humphreys paid tribute to the way the team had executed the game plan in a hostile environment against quality opposition.
Greig Laidlaw returns to the Gloucester Rugby squad this week, and his inclusion is an important one after a serious ankle injury. The Scottish scrum half is determined to drive the team forward in their European Rugby Challenge Cup semi final in La Rochelle this Saturday.
Gloucester take on La Rochelle in the European Rugby Challenge Cup semi-final in France on Saturday evening, with the Top 14 side the favourites in the eyes of the bookmakers. However, David Humphreys is looking for his side to rise to the occasion against a familiar opponent.
Local junior rugby teams had the honour of trotting out onto the Kingsholm pitch on Saturday morning, with over 400 young players representing their local clubs in the finals of the Wooden Spoon Charity Floodlit Tournament.