Gloucester's Olly Morgan starts at full-back for England U21s against Ireland at Dublin's Donnybrook ground on Friday 25th February, kick off 4pm.
Joining the squad for his first cap is Worcester back row Mark Hopley who starts at number eight in place of the injured Chris Goodman. An injury to Ross Broadfoot gives Falcons fly half Toby Flood his first start as Ryan Davis moves back to inside centre.
With Northampton Saints winger Paul Diggin also not considered due to injury, Topsy Ojo of London Irish joins the replacements.
Coach Nigel Redman said: "Ireland are always very strong and physical, particularly at home. We've watched their game against Scotland and they contested the breakdown very well and that's an area we needed to be sharper in.
"There are 10 changes to the starting side that played France for various reasons but all these guys train together as a squad during the week. Experience told us that we'd need this depth and that's the reason we extended the training squad to 26 players.
"As coaches it's a great chance for us to work with different players from all the clubs and get to know more about them and keep them all in our thoughts. At this level especially you don't always know who's going to be the best in a particular position and you have to consider everyone.
"Hopley was on the bench against Ireland for us last year and was a part of the trial games against France at the start of the season. We have some outstanding talent at back row with the likes of Goodman, Seymour, Rees, Haskell and Hopley and this is a fantastic opportunity for Mark.
"Opportunities come in many ways and injuries sometimes allow us to give some players the chance to come in and show us the work they've been doing and make us pick them next time.
"Topsy Ojo is another great example. He was in the U19 squad last year and he's in the Intermediate National Academy and he's available to us for the next two years."
15. Olly Morgan - Gloucester
14. Tom Biggs - Leeds Tykes
13. Matt Cornwell - Leicester Tigers
12. Ryan Davis - Bath
11. Tom Varndell - Leicester Tigers
10. Toby Flood - Newcastle Falcons
9. Ben Foden - Sale Sharks
1. Michael Cusack - Leeds Tykes
2. Neil Briggs - Rotherham
3. Aston Croall - Saracens
4. Richard Blaze - Worcester
5. Tom Ryder - Leicester Tigers
6. James Haskell - London Wasps
7. David Seymour - Saracens
8. Mark Hopley - Worcester
16. Stuart Mackie - Newcastle Falcons
17. Matt Hampson - Leicester Tigers
18. Sean Cox - Sale Sharks
19. Richard Thorpe - London Irish
20. Lee Dickson - Newcastle Falcons
21. Simon Whatling - Worcester
22. Topsy Ojo - London Irish
Nick Wood captained the Cherry and Whites on Saturday afternoon, and the experienced front rower expressed his pride in the young squad in defeat to Bath on the final day of the Aviva Premiership season.
Lewis Ludlow scored Gloucester's opening try in the 30-50 defeat at Bath on Saturday, part of an impressive performance by the young back row forward. Speaking after the game, he paid tribute to the young Gloucester side who went toe to toe with the Aviva Premiership semi-finalists.
Speaking to the local media after the game, Director of Rugby David Humphreys gave an honest assessment of the game, and expressed his pride in the way his young charges had performed against the title-chasing hosts.
Speaking to the local media this week, Gloucester Rugby scrum half Callum Braley is excited by the challenge of the West Country Derby, and the ex-Bristol man reveals the squad will be giving their all.
Speaking to the local media this week, David Humphreys admitted that team selection for Saturday's Aviva Premiership fixture at Bath has not been an easy one, with numerous players ruled out due to injury and suspension. However, he pledged that whoever is wearing the Cherry and White will be 100% committed to fighting until the very last minute.
Speaking to GRTV after the 35-13 Aviva Premiership victory over London Irish, Tom Savage praised his team mates for sticking to their game plan and showing real character to clinch an impressive win despite only playing with 14 men for nearly an hour.
Speaking to GRTV after the 35-13 win over London Irish at Kingsholm on Saturday, winger Henry Purdy explained that Gloucester keeping their collective composure after being reduced to 14 men was pivotal in clinching the win.
With Connacht Rugby the visitors to Kingsholm on Sunday (kick off 3:30pm) for Sunday's European Rugby Champions Cup play-off, Gloucester ring the changes from the side that took the field against Bath last weekend.
Matt Kvesic was a double winner at the Gloucester Rugby End of Season Awards Dinner on Tuesday, coupled with being named in the England Rugby training squad and the 23-year old is delighted with how his campaign has gone.
Gloucester Rugby held their End of Season Dinner at the Centaur at Cheltenham Racecourse this week. Amongst all the awards, Thinus Delport interviewed James Hook, Laurie Fisher, Charlie Sharples and Billy Twelvetrees.
On Tuesday evening, Gloucester Rugby held the 2015 End of Season Awards Dinner, at The Centaur, Cheltenham Racecourse, and the club photographer was on hand to capture snaps the guests and award winners.