Gloucester's Olly Morgan starts at full-back for England U21s against Ireland at Dublin's Donnybrook ground on Friday 25th February, kick off 4pm.
Joining the squad for his first cap is Worcester back row Mark Hopley who starts at number eight in place of the injured Chris Goodman. An injury to Ross Broadfoot gives Falcons fly half Toby Flood his first start as Ryan Davis moves back to inside centre.
With Northampton Saints winger Paul Diggin also not considered due to injury, Topsy Ojo of London Irish joins the replacements.
Coach Nigel Redman said: "Ireland are always very strong and physical, particularly at home. We've watched their game against Scotland and they contested the breakdown very well and that's an area we needed to be sharper in.
"There are 10 changes to the starting side that played France for various reasons but all these guys train together as a squad during the week. Experience told us that we'd need this depth and that's the reason we extended the training squad to 26 players.
"As coaches it's a great chance for us to work with different players from all the clubs and get to know more about them and keep them all in our thoughts. At this level especially you don't always know who's going to be the best in a particular position and you have to consider everyone.
"Hopley was on the bench against Ireland for us last year and was a part of the trial games against France at the start of the season. We have some outstanding talent at back row with the likes of Goodman, Seymour, Rees, Haskell and Hopley and this is a fantastic opportunity for Mark.
"Opportunities come in many ways and injuries sometimes allow us to give some players the chance to come in and show us the work they've been doing and make us pick them next time.
"Topsy Ojo is another great example. He was in the U19 squad last year and he's in the Intermediate National Academy and he's available to us for the next two years."
15. Olly Morgan - Gloucester
14. Tom Biggs - Leeds Tykes
13. Matt Cornwell - Leicester Tigers
12. Ryan Davis - Bath
11. Tom Varndell - Leicester Tigers
10. Toby Flood - Newcastle Falcons
9. Ben Foden - Sale Sharks
1. Michael Cusack - Leeds Tykes
2. Neil Briggs - Rotherham
3. Aston Croall - Saracens
4. Richard Blaze - Worcester
5. Tom Ryder - Leicester Tigers
6. James Haskell - London Wasps
7. David Seymour - Saracens
8. Mark Hopley - Worcester
16. Stuart Mackie - Newcastle Falcons
17. Matt Hampson - Leicester Tigers
18. Sean Cox - Sale Sharks
19. Richard Thorpe - London Irish
20. Lee Dickson - Newcastle Falcons
21. Simon Whatling - Worcester
22. Topsy Ojo - London Irish
Skipper Billy Twelvetrees told GRTV after the win in Brive that the game could have been a tough one to get up for, but that his Gloucester team mates did themselves proud on the night and got a big result.
Reflecting on the 31-20 victory in Brive on Thursday evening, Director of Rugby David Humphreys said that clinching a home European Rugby Challenge Cup quarter-final was the overall aim and duly achieved.
Gloucester may have already clinched a home European Rugby Challenge Cup quarter-final, but Director of Rugby David Humphreys wants his side to finish the pool stages on a winning note in Brive on Thursday evening.
Speaking after Saturday's win, James Hudson was happy to record a bonus-point win against a hugely physical Oyonnax side as Gloucester secured their passage into the European Rugby Challenge Cup Quarter Finals
Billy Burns was a try scorer on his first European start for Gloucester and, speaking after the game, admitted that it was good to get the five points although there are still things to work on before the trip to Brive.
Connacht's 30-20 win in La Rochelle on Saturday evening means that they are the third best placed runners up and will come to Kingsholm for the quarter-final of the European Rugby Challenge Cup in early April.
Gloucester Rugby today confirmed that supporters who have renewed their Club Membership for next season by March 27th 2015 will receive a free ticket for this season's European Rugby Challenge Cup quarter-final at Kingsholm in April.
It was a bit of an arm wrestle at times, but two tries in each half did the trick for Gloucester as they defeated CA Brive by 31 points to 20 at the Stade Amedee-Domench on Thursday evening to secure top seeding for the quarter-finals.