Gloucester's Olly Morgan starts at full-back for England U21s against Ireland at Dublin's Donnybrook ground on Friday 25th February, kick off 4pm.
Joining the squad for his first cap is Worcester back row Mark Hopley who starts at number eight in place of the injured Chris Goodman. An injury to Ross Broadfoot gives Falcons fly half Toby Flood his first start as Ryan Davis moves back to inside centre.
With Northampton Saints winger Paul Diggin also not considered due to injury, Topsy Ojo of London Irish joins the replacements.
Coach Nigel Redman said: "Ireland are always very strong and physical, particularly at home. We've watched their game against Scotland and they contested the breakdown very well and that's an area we needed to be sharper in.
"There are 10 changes to the starting side that played France for various reasons but all these guys train together as a squad during the week. Experience told us that we'd need this depth and that's the reason we extended the training squad to 26 players.
"As coaches it's a great chance for us to work with different players from all the clubs and get to know more about them and keep them all in our thoughts. At this level especially you don't always know who's going to be the best in a particular position and you have to consider everyone.
"Hopley was on the bench against Ireland for us last year and was a part of the trial games against France at the start of the season. We have some outstanding talent at back row with the likes of Goodman, Seymour, Rees, Haskell and Hopley and this is a fantastic opportunity for Mark.
"Opportunities come in many ways and injuries sometimes allow us to give some players the chance to come in and show us the work they've been doing and make us pick them next time.
"Topsy Ojo is another great example. He was in the U19 squad last year and he's in the Intermediate National Academy and he's available to us for the next two years."
15. Olly Morgan - Gloucester
14. Tom Biggs - Leeds Tykes
13. Matt Cornwell - Leicester Tigers
12. Ryan Davis - Bath
11. Tom Varndell - Leicester Tigers
10. Toby Flood - Newcastle Falcons
9. Ben Foden - Sale Sharks
1. Michael Cusack - Leeds Tykes
2. Neil Briggs - Rotherham
3. Aston Croall - Saracens
4. Richard Blaze - Worcester
5. Tom Ryder - Leicester Tigers
6. James Haskell - London Wasps
7. David Seymour - Saracens
8. Mark Hopley - Worcester
16. Stuart Mackie - Newcastle Falcons
17. Matt Hampson - Leicester Tigers
18. Sean Cox - Sale Sharks
19. Richard Thorpe - London Irish
20. Lee Dickson - Newcastle Falcons
21. Simon Whatling - Worcester
22. Topsy Ojo - London Irish
Ahead of Friday evening's Aviva Premiership fixture away at London Welsh, Head Coach Laurie Fisher told the local media that he feels that Gloucester are making improvements each and every week but that there's still plenty of work to do.
Speaking to GRTV on Monday night, Pete Buxton was thrilled with the spirit shown by the Gloucester United squad as they overturned a twenty-one point deficit in the second half to overcome Bristol Rugby.
Scrum half Callum Braley was a try scorer in Gloucester United's 30-27 win over Bristol United in the Aviva Premiership A League on Monday evening and, after the game, paid tribute to his team mates for hanging in there and fighting back to get the win.
Skipper Billy Twelvetrees admitted that the Gloucester squad were disappointed and frustrated after losing at home to Exeter, regretting that Gloucester's own errors had given the Chiefs the upper hand.
Gloucester Rugby is rightly proud of the work that it does within the community and is delighted to confirm that it will be working with Gloucestershire Young Carers and Pied Piper as its two chosen charities this season.