Gloucester's Olly Morgan starts at full-back for England U21s against Ireland at Dublin's Donnybrook ground on Friday 25th February, kick off 4pm.
Joining the squad for his first cap is Worcester back row Mark Hopley who starts at number eight in place of the injured Chris Goodman. An injury to Ross Broadfoot gives Falcons fly half Toby Flood his first start as Ryan Davis moves back to inside centre.
With Northampton Saints winger Paul Diggin also not considered due to injury, Topsy Ojo of London Irish joins the replacements.
Coach Nigel Redman said: "Ireland are always very strong and physical, particularly at home. We've watched their game against Scotland and they contested the breakdown very well and that's an area we needed to be sharper in.
"There are 10 changes to the starting side that played France for various reasons but all these guys train together as a squad during the week. Experience told us that we'd need this depth and that's the reason we extended the training squad to 26 players.
"As coaches it's a great chance for us to work with different players from all the clubs and get to know more about them and keep them all in our thoughts. At this level especially you don't always know who's going to be the best in a particular position and you have to consider everyone.
"Hopley was on the bench against Ireland for us last year and was a part of the trial games against France at the start of the season. We have some outstanding talent at back row with the likes of Goodman, Seymour, Rees, Haskell and Hopley and this is a fantastic opportunity for Mark.
"Opportunities come in many ways and injuries sometimes allow us to give some players the chance to come in and show us the work they've been doing and make us pick them next time.
"Topsy Ojo is another great example. He was in the U19 squad last year and he's in the Intermediate National Academy and he's available to us for the next two years."
15. Olly Morgan - Gloucester
14. Tom Biggs - Leeds Tykes
13. Matt Cornwell - Leicester Tigers
12. Ryan Davis - Bath
11. Tom Varndell - Leicester Tigers
10. Toby Flood - Newcastle Falcons
9. Ben Foden - Sale Sharks
1. Michael Cusack - Leeds Tykes
2. Neil Briggs - Rotherham
3. Aston Croall - Saracens
4. Richard Blaze - Worcester
5. Tom Ryder - Leicester Tigers
6. James Haskell - London Wasps
7. David Seymour - Saracens
8. Mark Hopley - Worcester
16. Stuart Mackie - Newcastle Falcons
17. Matt Hampson - Leicester Tigers
18. Sean Cox - Sale Sharks
19. Richard Thorpe - London Irish
20. Lee Dickson - Newcastle Falcons
21. Simon Whatling - Worcester
22. Topsy Ojo - London Irish
When he joins Gloucester Rugby later this summer, Matt Kvesic will do so as a full England international. The openside flanker has been named to start against Argentina on Saturday and spoke to RFU.com about the prospect.
Ben Morgan, Tom Johnson and Henry Thomas spoke to Russ Hargreaves this week as they were about to do some DIY work at Chobham RFC as part of Natwest Rugby Force. On the agenda for discussion were, of course, England's forthcoming games but also the trio's painting prowess.
With ADEY Professional Heating Solutions now unveiled as Gloucester Rugby's new main sponsor from July 2013, managing Director Kelvin Stevens spoke to the club website about the reasons for getting involved with the club.
Gloucester Rugby CEO Stephen Vaughan was delighted to introduce ADEY Professional Heating Solutions as the club's new main sponsor this week. He spoke to the club website about the exciting new partnership.
Although understandably disappointed following the 40-39 defeat at Exeter, Freddie Burns thought that both teams fully contributed to a great spectacle but that a couple of refereeing decisions were key to the outcome.
Gloucester's final game of the season ended in a narrow defeat in a pulsating encounter at the Exeter Chiefs. The Cherry and Whites went down 40-39, as Gareth Steenson's dramatic late penalty meant that the end of Director of Rugby Nigel Davies' first season in charge ended in defeat. Davies spoke to the official website in the Devon sunshine.
Dave Lewis was in a tough situation on Saturday afternoon - playing for Gloucester against the side he will join next season, Exeter Chiefs. At the final whistle though, Lewis was simply disappointed to have lost the game.
The Gloucester Rugby Academy has established a production line of rugby talent in recent times, and Assistant Academy Manager Simon Lane is confident that the latest generation are going to step up to the mark.
Ross Moriarty and Elliott Stooke have both been named in the England U20s side to take on New Zealand in the semi-final of the IRB Junior World Championship in Vannes, France, on Tuesday June 18, kick off 1945 (GMT).
The J.P. Morgan Premiership Rugby 7s Series sweeps across the country this summer with pool matches at Gloucester Rugby, Northampton Saints and Saracens on 1,2 and 3 August, and the Final at Bath Rugby on 9 August.
British and Irish Lions Head Coach Warren Gatland has named his squad for the match in Canberra against Super 15 side ACT Brumbies, with injuries hitting the squad Gloucester Rugby's Billy Twelvetrees was drafted in to the touring party and he starts at inside-centre for Tuesday's match.
It was an historic night for England as, for the first time, they completed back to back wins in Argentina with a 51-26 triumph. Freddie Burns scored 19 points on an evening which also saw Jonny May win his first cap.