Gloucester's Olly Morgan starts at full-back for England U21s against Ireland at Dublin's Donnybrook ground on Friday 25th February, kick off 4pm.
Joining the squad for his first cap is Worcester back row Mark Hopley who starts at number eight in place of the injured Chris Goodman. An injury to Ross Broadfoot gives Falcons fly half Toby Flood his first start as Ryan Davis moves back to inside centre.
With Northampton Saints winger Paul Diggin also not considered due to injury, Topsy Ojo of London Irish joins the replacements.
Coach Nigel Redman said: "Ireland are always very strong and physical, particularly at home. We've watched their game against Scotland and they contested the breakdown very well and that's an area we needed to be sharper in.
"There are 10 changes to the starting side that played France for various reasons but all these guys train together as a squad during the week. Experience told us that we'd need this depth and that's the reason we extended the training squad to 26 players.
"As coaches it's a great chance for us to work with different players from all the clubs and get to know more about them and keep them all in our thoughts. At this level especially you don't always know who's going to be the best in a particular position and you have to consider everyone.
"Hopley was on the bench against Ireland for us last year and was a part of the trial games against France at the start of the season. We have some outstanding talent at back row with the likes of Goodman, Seymour, Rees, Haskell and Hopley and this is a fantastic opportunity for Mark.
"Opportunities come in many ways and injuries sometimes allow us to give some players the chance to come in and show us the work they've been doing and make us pick them next time.
"Topsy Ojo is another great example. He was in the U19 squad last year and he's in the Intermediate National Academy and he's available to us for the next two years."
15. Olly Morgan - Gloucester
14. Tom Biggs - Leeds Tykes
13. Matt Cornwell - Leicester Tigers
12. Ryan Davis - Bath
11. Tom Varndell - Leicester Tigers
10. Toby Flood - Newcastle Falcons
9. Ben Foden - Sale Sharks
1. Michael Cusack - Leeds Tykes
2. Neil Briggs - Rotherham
3. Aston Croall - Saracens
4. Richard Blaze - Worcester
5. Tom Ryder - Leicester Tigers
6. James Haskell - London Wasps
7. David Seymour - Saracens
8. Mark Hopley - Worcester
16. Stuart Mackie - Newcastle Falcons
17. Matt Hampson - Leicester Tigers
18. Sean Cox - Sale Sharks
19. Richard Thorpe - London Irish
20. Lee Dickson - Newcastle Falcons
21. Simon Whatling - Worcester
22. Topsy Ojo - London Irish
Matt Scott made his first appearance in Cherry and White on Saturday afternoon, and despite a narrow loss to Leinster, the Scotsman highlighted a lot to be pleased about after the first hit out of the new season.
Lloyd Evans will assume a senior role in the Gloucester Rugby squad as they head to Franklin's Gardens for the Singha Premiership Rugby 7s on Friday evening. The exciting Academy fly half spoke to GRTV this week ahead of the season curtain-raiser.
Summer signing Matt Scott met with the local media for the first time this week and said that he's settling in well at Gloucester, that hopes are high for the forthcoming season and that skipper Greig Laidlaw had done a good sales pitch when it came to him signing!
Olly Morgan is heading up Gloucester's Singha Premiership 7s once again this summer and, with the start of the tournament just around the corner, he's looking for some of the club's younger players to make the most of the playing time and the exposure it offers.
The Cherry & Whites are now in their second full week of preseason ahead of the new season, and GRTV caught up with the new Head of Strength & Conditioning Dan Tobin to chat about what is in store, and his first impressions of the club.
Speaking exclusively to GRTV before Wales set off for Twickenham on Friday afternoon, Ross Moriarty chatted about the prospect of taking on England on Sunday as well as the challenge of the subsequent tour to New Zealand.
Brighton is the venue of choice for England this week as the squad have reported for a training camp to prepare for the upcoming international against Wales. GRTV caught up with Gloucester's Matt Kvesic after the first day's training.
This Bank Holiday Weekend, Gloucester Rugby take over the Gloucester Quays again for the Beach Weekender, with two 20-metre beaches set up for a weekend of sporting fun and entertainment, in the heart of Gloucester Quays.
Gloucester Rugby has always been very active in the local community, promoting grassroots rugby and delivering programmes to underprivileged children, and recently we received the news that we had achieved registered charity status to allow us to continue what we've been doing and grow our programmes across the county.
Gloucester Rugby are joining forces with main club partners Mitsubishi Motors in scrumming down with legends of rugby union and rugby league for a hybrid match with aims to raise thousands of pounds for charity at the same time.