Duncan McRae returns to the number 10 shirt for the first time since the visit to NEC Harlequins at the beginning of February, after coming through 65 minutes of the second team win over Saracens on Monday.
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James Simpson-Daniel starts at outside centre after missing the win over London Irish two weeks ago with a virus.
Welsh hooker Mefin Davies makes his first start for Gloucester since his successful Six Nations campaign after recovering from a leg injury.
The 32 year-old lines up alongside Gary Powell (tight-head) and Olivier Azam, who moves to loose-head.
The pack also welcomes back number eight James Forrester, who takes the place of Adam Balding.
25 year-old Balding misses out with a stomach muscle injury picked up against London Irish, and Jake Boer takes over the captaincy.
Boer starts at open-side with England international Andy Hazell ruled out after the knock to the head he picked up in the win at the Madejski Stadium two weeks ago. Peter Buxton completed the back-row at number six.
Alex Page continues at scrum-half, and Andy Gomarsall returns to the matchday squad on the bench, alongside Brad Davies and Mark Foster, who impressed in Monday's Zurich 'A' League win.
As well as Balding and Hazell ruled out, other players unavailable include Phil Vickery (arm), Henry Paul (knee), Chris Fortey (ankle), Mark Cornwell (neck) and James Parkes (wrist).
Tickets are available for the clash with Leeds at Kingsholm from www.gloucesterrugbyclub.com, 0871 871 8781 or from the ticket office at the ground.
Gloucester:
15. Jon Goodridge
14. Marcel Garvey
13. James Simpson-Daniel
12. Terry Fanolua
11. Seti Kiole
10. Duncan McRae
9. Alex Page
1. Olivier Azam
2. Mefin Davies
3. Gary Powell
4. Adam Eustace
5. Alex Brown
6. Peter Buxton
7. Jake Boer (c)
8. James Forrester
Replacements:
16. Nick Wood
17. Terry Sigley
18. Luke Narraway
19. James Merriman
20. Andy Gomarsall
21. Brad Davies
22. Mark Foster
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