GARTEH COOPER will start his second Guinness Premiership match of the season at scrum-half when table-topping Gloucester travel to Newcastle on Sunday (3pm).
The Wales number nine comes into the team for Rory Lawson in one of three changes to the side that beat Bourgoin 51-27 at Kingsholm last Saturday.
Marco Bortolami returns to the second row as captain in place of Peter Buxton, who moves to the bench and Alasdair Strokosch starts at number six which means Luke Narraway shifts to the openside in place of Akapusi Qera, who is ruled out with a slight wrist injury.
The rest of Ryan's line-up remains intact for what potentially could be one of the most exciting games of the season between two sides stacked with English talent.
"It is impossible to believe we can operate with the same group of players relentlessly throughout the season because we have been through a very intense period of matches and we are not going to get the best from a guy like Pete Buxton if we simply play and play him," Ryan said.
"We are bringing in an international captain and outstanding player in Marco Bortolami to the second row, Gareth Cooper has looked sharp in his appearances from the bench and Strokosch gives us a work ethic and explosive power we will require.
"Newcastle away from home is one of the most demanding fixtures in the Premiership - they have an outstanding spine to their team and world class players in key areas - it is a hugely important game for both of us.
"I think both teams like to try and play rugby in the right way and that is a great endorsement to both clubs and also the Premiership."
Bortolami's last start was against the Dragons in the EDF Energy Cup at the end of November and he will partner Alex Brown at lock. The front row of Nick Wood, hooker Olivier Azam and tight-head Carlos Nieto remains intact.
Narraway, who has operated at numbers eight and six this season switches to the openside flank, Strokosch comes in at six and Gareth Delve will start his fifth successive game at number eight.
Outside Cooper, Ryan Lamb will wear number 10 and will face Jonny Wilkinson, Anthony Allen and Mike Tindall feature in midfield, while Lesley Vainikolo, the Premiership's leading try scorer with seven; James Simpson-Daniel and Iain Balshaw complete the back three.
The bench is again made into a four-three forward split. Andy Titterrell and Patrice Collazo are the front row replacements and Will James and Buxton the back five options.
Scrum-half Lawson, utility back Willie Walker, who scored against Bourgoin last Saturday and Leon Lloyd complete the three-quarter options.
GLOUCESTER (v Newcastle, Sunday): Iain Balshaw, James Simpson-Daniel, Mike Tindall, Anthony Allen, Lesley Vainikolo; Ryan Lamb, Gareth Cooper; Nick Wood, Olivier Azam, Carlos Nieto, Marco Bortolami (capt), Alex Brown, Alasdair Strokosch, Luke Narraway, Gareth Delve. Reps: Andy Titterrell, Patrice Collazo, Will James, Peter Buxton, Rory Lawson, Willie Walker, Leon Lloyd.
Speaking with the local media before the Gloucester team set off on the long trip north to Newcastle, Director of Rugby David Humphreys discussed his team selection and stated that Friday night's meeting will be a challenging one.
Speaking to the local media on Thursday, Matt Kvesic was looking forward to the trip to Newcastle Falcons, and the captain is looking to lead from the front with plenty for the Cherry and Whites to work on.
Gloucester saw a 12-0 lead overturned by Harlequins on Friday night as the visitors ran out 22-15 winners. After the game, Director of Rugby David Humphreys spoke about missed opportunities on the night.
Speaking to the local media on Thursday, James Hudson explained his excitement for tonight's game with Harlequins and that he is backing the Cherry and White squad to impress during the next set of Aviva Premiership games.
Despite a dream start at Kingston Park, scoring a try after just 26 seconds, Gloucester couldn't capitalise against a dogged Newcastle Falcons side. Too many penalties were conceded and too many errors made as the Falcons prevailed 20-10.
There are three changes to Gloucester Rugby's starting line-up for Friday evening's Aviva Premiership fixture away at Newcastle Falcons. Steve McColl will make his first Premiership start for the club.