GARTEH COOPER will start his second Guinness Premiership match of the season at scrum-half when table-topping Gloucester travel to Newcastle on Sunday (3pm).
The Wales number nine comes into the team for Rory Lawson in one of three changes to the side that beat Bourgoin 51-27 at Kingsholm last Saturday.
Marco Bortolami returns to the second row as captain in place of Peter Buxton, who moves to the bench and Alasdair Strokosch starts at number six which means Luke Narraway shifts to the openside in place of Akapusi Qera, who is ruled out with a slight wrist injury.
The rest of Ryan's line-up remains intact for what potentially could be one of the most exciting games of the season between two sides stacked with English talent.
"It is impossible to believe we can operate with the same group of players relentlessly throughout the season because we have been through a very intense period of matches and we are not going to get the best from a guy like Pete Buxton if we simply play and play him," Ryan said.
"We are bringing in an international captain and outstanding player in Marco Bortolami to the second row, Gareth Cooper has looked sharp in his appearances from the bench and Strokosch gives us a work ethic and explosive power we will require.
"Newcastle away from home is one of the most demanding fixtures in the Premiership - they have an outstanding spine to their team and world class players in key areas - it is a hugely important game for both of us.
"I think both teams like to try and play rugby in the right way and that is a great endorsement to both clubs and also the Premiership."
Bortolami's last start was against the Dragons in the EDF Energy Cup at the end of November and he will partner Alex Brown at lock. The front row of Nick Wood, hooker Olivier Azam and tight-head Carlos Nieto remains intact.
Narraway, who has operated at numbers eight and six this season switches to the openside flank, Strokosch comes in at six and Gareth Delve will start his fifth successive game at number eight.
Outside Cooper, Ryan Lamb will wear number 10 and will face Jonny Wilkinson, Anthony Allen and Mike Tindall feature in midfield, while Lesley Vainikolo, the Premiership's leading try scorer with seven; James Simpson-Daniel and Iain Balshaw complete the back three.
The bench is again made into a four-three forward split. Andy Titterrell and Patrice Collazo are the front row replacements and Will James and Buxton the back five options.
Scrum-half Lawson, utility back Willie Walker, who scored against Bourgoin last Saturday and Leon Lloyd complete the three-quarter options.
GLOUCESTER (v Newcastle, Sunday): Iain Balshaw, James Simpson-Daniel, Mike Tindall, Anthony Allen, Lesley Vainikolo; Ryan Lamb, Gareth Cooper; Nick Wood, Olivier Azam, Carlos Nieto, Marco Bortolami (capt), Alex Brown, Alasdair Strokosch, Luke Narraway, Gareth Delve. Reps: Andy Titterrell, Patrice Collazo, Will James, Peter Buxton, Rory Lawson, Willie Walker, Leon Lloyd.
Speaking to the media following the 31-33 West Country Challenge Cup defeat to Exeter Chiefs at the Memorial Stadium, Director of Rugby David Humphreys was full of praise for his side's battling qualities in a bruising encounter but concerned about the injuries picked up.
The West Country Challenge Cup fixture against the Exeter Chiefs at the Memorial Stadium in Bristol on Saturday (kick off 3pm) will be Gloucester's last chance to work on things like new combinations says Director of Rugby, David Humphreys.
Speaking after the 30-21 West Country Challenge Cup defeat at Bath, Director of Rugby David Humphreys spoke of the improvements his team are making as preseason progresses but acknowledges that there is still work to do ahead of the start of the Aviva Premiership.
Speaking to the local media ahead of Saturday's trip to Bath Rugby in the West Country Challenge Cup, front rower Nick Wood spoke of the hard work put in across the extended preseason and highlighted the competition for front row spots in the squad.
Gloucester have named a 30 man squad for the latest round of West Country Challenge Cup action against Bath on Saturday, with Director of Rugby David Humphreys stressing the need to keep an eye on player workload ahead of what will be a long, tough season.
Describing the 50-7 West Country Challenge Cup win over Bath on Sunday as a '...good hit out...', wing Charlie Sharples admitted that it had been a good opportunity to put into practice things that the squad have been trying out in training in recent weeks.
Speaking to the local media after the 50-7 victory over Bath Rugby on Sunday, David Humphreys was happy with his squad's effort, with the most important aspect being the game time earned by his players.
Gloucester make wholesale changes to the side that started at Exeter last Saturday as they prepare to take on Bath at the Memorial Stadium, Bristol on Sunday in the West Country Challenge Cup (kick off 3pm). The Director of Rugby told GRTV that the players are raring to go and that he's looking forward to seeing different combinations in action.