The omens were not good in the build-up to the game, with Mills failing to recover from a knee injury sustained in the previous weeks triumph over Moulton College and Evans suffering from a back problem.
To make matters worse, vice captain Harry Casson, now skipper in Mills' absence, rolled his ankle in the team run the day before the match, but manfully took to the field against Worcester despite being in some discomfort.
The coaches made a number of changes to the team that started against Moulton. The enforced replacements were Miller for Mills and Casson for Evans, with fullback Josh Hawkins and hooker Josh Gape also making way for Max Davies and Will Tanner respectively.
Hartpury drew first blood when they were awarded and scored a fifth-minute penalty forty metres from the Worcester line after the latter failed to roll away at the tackle, Dan Robson nailing a sweet strike.
Robson doubled the lead four minutes later with a simple second penalty after the hosts were penalised for the same offence, before Louis Spencer had the honour of scoring the first of four Hartpury tries to be scored that day with fifteen minutes on the clock converted well by Robson, which extended the visitors lead to thirteen unanswered points.
The home side exerted some pressure of their own, and perhaps they should have scored when their talented England number eight broke clear off the back of a scrum on the Hartpury 22 and offloaded, only for the supporting player to drop the ball with the line at his mercy.
After the initial intensity of the encounter somewhat fizzled out as time went on, both teams came out re-energised after the break and all guns blazing at the start of the second half.
The opening exchanges of the second period echoed those of the first, both sides engaging in a game of chess and eager not to make a game-changing mistake. It took ten minutes for an event of any note to take place, when Louis Spencer grabbed his and Hartpury's second try.
A lineout five metres from the Worcester line was secured, a driving maul was initiated, and Spencer was the lucky man at the back who had the simple task of dotting the ball down and hence revelling in the glory.
It was not without controversy as the hosts complained that the ball was held up, but the try stood to make the score a handsome 18-0. Robson hooked his conversion attempt, but the home side now required three tries to go ahead in the match.
Worcester looked like they may have crumbled when the restart was kicked out on the full and locks Rob Langley and James Clutterbuck began to deny them any lineout ball, but they hit back with a try to keep the game alive.
The visitors had been stretched and the hosts' winger went over in the corner for a try which kept the game alive, particularly when it was converted expertly. At 18-7, Worcester had renewed hope of claiming at least a losing bonus point, especially when Hartpury captain Casson had to go off courtesy of his damaged ankle.
However, that hope was quashed with ten minutes remaining when the league leaders ran in their third try to make the game effectively safe. James Miller breezed through a wall of red shirts with consummate ease, making thirty metres before getting the ball away to his centre partner Sanders.
He was tackled short of the line, but the ball was swiftly recycled and Dan Robson applied the finishing touch, diving in under the posts which left him with an easy conversion for a 25-7 score line.
Worcester's woes were compounded when referee Kitt lost patience with their flanker and sin binned him after he slowed down a menacing Hartpury attack illegally, meaning that they would have to play the last eight minutes with fourteen men. Dan Robson punished him further for that infringement by adding another three points.
Ian Clark guaranteed that Hartpury would be going back to Gloucestershire with maximum points as he made their superior numbers count and scored the coveted fourth try.
Just inside his own half, he received the ball in the wing position that he has made his own this season after great hands from Casson's replacement Alex Hughes, skinned the onrushing defender and finished the job in style to send his team mates into raptures.
Robson missed a relatively simple conversion with a scuffed effort, and Clark was involved in two final thrusts at the Worcester line which could and maybe should have borne fruit, but it was no matter as Hartpury knew that they were going home victorious 33-7.
Junior Academy Director Alan Martinovic was delighted with the result and the improvement on last weeks performance.
"It was an outstanding result and I am happy to see that we rectified some of the bad things about the Moulton game.
"Our scrum and lineout was a lot more secure today, particularly when we got into attacking positions.
I was very pleased with the way that we executed our kicking strategy as well. It put Worcester under a lot of pressure."
Hartpury College Squad:
1 Taylor 2 Tanner 3 Heard 4 Langley 5 Clutterbuck 6 Hull 7 Spencer (2t) 8 Casson (captain) 9 Kettlewell 10 Robson (1t, 2c, 3p) 11 Clark (1t) 12 Miller 13 Harry Sanders 14 Price 15 Davies 16 Gape 17 Tom Sanders 18 Litchfield (Heard) 19 Woodburn (Spencer) 20 Hughes (Casson) 21 Hawkins (Davies) 22 Gibbs
Man of the Match: Louis Spencer