There are two changes to the pack that started against Italy with Joe Marler (Harlequins) replacing Mako Vunipola (Saracens) at loose-head prop and Tom Croft (Leicester Tigers) starting at blindside flanker in place of James Haskell (London Wasps).
England Head Coach Stuart Lancaster said:
"We have come a long way through the QBE series and the Six Nations and we want to finish well on what will be a fantastic occasion in Cardiff. It will be a great experience for our English team.
"Every single player, whether they are in the 23 or not this Saturday, has contributed to getting us in this position and they should be proud of that.
"The support of the country has been great throughout the tournament and I am sure they will be right behind us come 5 o'clock."
England (v Wales, Saturday, 5pm, Millennium Stadium, live on BBC One)
15. Alex Goode (Saracens, 10 caps)
14. Chris Ashton (Saracens, 33 caps)
13. Manusamoa Tuilagi (Leicester Tigers, 20 caps)
12. Brad Barritt (Saracens, 15 caps)
11. Mike Brown (Harlequins, 15 caps)
10. Owen Farrell (Saracens, 15 caps)
9. Ben Youngs (Leicester Tigers, 32 caps)
1. Joe Marler (Harlequins, 9 caps)
2. Tom Youngs (Leicester Tigers, 8 caps)
3. Dan Cole (Leicester Tigers, 39 caps)
4. Joe Launchbury (London Wasps, 8 caps)
5. Geoff Parling (Leicester Tigers, 16 caps)
6. Tom Croft (Leicester Tigers, 37 caps)
7. Chris Robshaw (Harlequins, capt, 16 caps)
8. Tom Wood (Northampton Saints, 17 caps)
16. Dylan Hartley (Northampton Saints, 46 caps)
17. David Wilson (Bath Rugby, 25 caps)
18. Mako Vunipola (Saracens, 8 caps)
19. Courtney Lawes (Northampton Saints, 19 caps)
20. James Haskell (London Wasps, 49 caps)
21. Danny Care (Harlequins, 40 caps)
22. Toby Flood (Leicester Tigers, 56 caps)
23. Billy Twelvetrees (Gloucester Rugby, 3 caps)